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April 22, 2015 - 17.00 h s.t., Seminar Room 0.15/N100
Structural basis of bacterial multi drug efflux transport
Prof. Dr. Akihito Yamaguchi, Osaka University / Japan

July 13-16, 2015 - Ellwangen Conference Center Schönenberg
SFB 807 Retreat 2015
Registration for SFB 807 members, co-workers & TRAM-students is open now!

April 29, 2015 - 17.00 h s.t. Seminar Room 0.15 / N100
Nucleotide-binding domain motions during gating in CFTR channels, the ABC proteins whose dysfunction causes cystic fibrosis
Prof. Dr. David Gadsby, The Rockefeller University, New York, USA

SFB 807 Transport and Communication across Biological Membranes

Membrane Proteine, Membrane Biology, Membrane Biochemistry

Biological membranes are intimately associated with the evolution of life, providing a barrier to or within the cell that allows for compartmentalization and structure formation as well as concentration of molecules. However, any living cell has to communicate via this barrier with its environment and, therefore, membranes are equipped with a multitude of membrane proteins that are required for uptake and export of molecules, and for communication across this barrier (sensing of stimuli and signal transduction to intracellular targets). This pivotal role of membrane proteins is exemplified in genomes from all kingdoms of life, in which 25-30% of the genetic information encodes for membrane proteins. Despite their importance for the physiology of cells, a precise understanding of membrane proteins and processes are only rarely available. In particular, transport processes and information transfer are often not well resolved, even though they are of paramount interest from a biomedical standpoint of view as reflected by the fact that roughly 60% of the currently used medical drugs target transmembrane processes. This discrepancy between our knowledge and the importance of transmembrane processes will ensure that this research area will stay in the focus both of academic research as well as the pharmaceutical industry for years to come.


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