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Müller (P14) | Meier (P15) | Tampé (P16) | Schleiff (P17) | Pos (P18) | Schäfer (P19)

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Membrane transport machineries are multi-protein complexes embedded in or associated with the biological membrane and are involved in the transport of various compounds, ranging from ions to drugs, peptides and proteins, across these membranes. These processes are energized by the ion-motive force and/or by the use of the free energy of binding/hydrolysis of ATP and/or GTP. Despite the different modes of energy coupling and their specialized location in different biological membranes, these macromolecular membrane complexes share the transduction of (electro) chemical energy into the common function of solute transport across membranes. Whereas many single-component transporters have been functionally and structurally characterized including high-resolution structures and reconstitution into lipid membranes to show transport, multi-component membrane complexes are still poorly characterized in many aspects. They include the fascinating features of allosteric coupling and comprise the modulation of their core activities by covalent or non-covalent modifications using additional proteins, lipids, or smaller compounds. These aspects, which are inherently associated with multi-component transport machineries, are another focus of this CRC.

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