January 30, 2019 - 13 h s.t., Biocenter N100/R015
Efflux pumps from Gram negative bacteria: from in vitro minimal systems to the complexity of the bacterial membrane

Prof. Dr. Martin Picard, Institut de Biologie Physico-Chimique, Paris / France

February 6, 2019 - 13 h s.t., Biocenter N100 / 015
Electron microscopy approaches to studying lipid-protein interactions

Prof. Dr. Thomas Walz, The Rockefeller University New York / USA

February 13, 2019 - 13 h s.t., Biocenter N100/R015
Driving forces of greasy membrane protein association in greasy membranes

Prof. Dr. Janice L. Robertson, Washington University, St. Louis/ USA

SFB 807 Transport and Communication across Biological Membranes

Membrane Proteine, Membrane Biology, Membrane Biochemistry

The objective of the Collaborative Research Center, CRC 807, is to elucidate the structure, function, and mechanism of membrane proteins involved in transfer of matter and information across cell membranes. Research interests range from small functional units to large, highly dynamic multi-subunit assemblies in subcellular compartments. Methods cover X-ray crystallography, cryo-electron microscopy, solid-state and solution NMR, pulsed EPR, time-resolved visible and infrared spectroscopy, single-molecule fluorescence techniques, super-resolution microscopy, native mass spectrometry, electrophysiology, and computational biophysics. Members of the CRC 807 (Sonderforschungsbereich SFB 807) collaborate on integrative biological questions, applying as well as developing advanced methodology. As many important questions cannot yet be answered by routine approaches, the development of methods constitutes an integral part of the CRC 807. Thus, the
CRC 807 rests on a well-balanced combination of enthralling topics, timely questions, and new approaches, probing the structure, function, and mechanism of membrane proteins.

The CRC 807 focuses on five subtopics: (i) secondary active transporters, (ii) ABC transporters, (iii) 7TM receptors and retinal proteins, (iv) rotary ATPases, and (v) membrane complexes. This outline implies a gradual increase in complexity. Hence, our CRC application spans the range from single transporter/receptor units to dynamic multi-component membrane assemblies, which will be a major challenge in life sciences.



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