Prof. Dr. Stephen H. White, University of California, Irvine / USA
Prof. Dr. Daniel Rosenbraum, UT Southwestern, Texas / USA
The objective of the Collaborative Research Center, CRC 807, is to elucidate the structure, function, and mechanism of membrane proteins involved in transfer of matter and information across cell membranes. Research interests range from small functional units to large, highly dynamic multi-subunit assemblies in subcellular compartments. Methods cover X-ray crystallography, cryo-electron microscopy, solid-state and solution NMR, pulsed EPR, time-resolved visible and infrared spectroscopy, single-molecule fluorescence techniques, super-resolution microscopy, native mass spectrometry, electrophysiology, and computational biophysics. Members of the CRC 807 (Sonderforschungsbereich SFB 807) collaborate on integrative biological questions, applying as well as developing advanced methodology. As many important questions cannot yet be answered by routine approaches, the development of methods constitutes an integral part of the CRC 807. Thus, the
CRC 807 rests on a well-balanced combination of enthralling topics, timely questions, and new approaches, probing the structure, function, and mechanism of membrane proteins.
The CRC 807 focuses on five subtopics: (i) secondary active transporters, (ii) ABC transporters, (iii) 7TM receptors and retinal proteins, (iv) rotary ATPases, and (v) membrane complexes. This outline implies a gradual increase in complexity. Hence, our CRC application spans the range from single transporter/receptor units to dynamic multi-component membrane assemblies, which will be a major challenge in life sciences.