May 3, 2017 - 17.00 h s.t., seminar room 015/N100
Using in vitro and in vivo single-molecule fluorescence to unravel transcription mechanisms

Prof. Dr. Achillefs Kapanidis, University of Oxford / UK

May 9-12, 2017 - Riedberg Campus
Lecture Series: Random Walks Among Ion Channels

TRAM-Professorship 2017: Prof. Dr. Chris Miller, Brandeis University in Waltham / USA

May 17, 2017 - 17.00 h s.t., Seminar Room 0.15/N100
Flagellar Ca2+ signaling nanodomains in regulating sperm motility and navigation

Prof. Dr. Jean-Ju Chung, Yale School of Medicine / USA

SFB 807 Transport and Communication across Biological Membranes

Membrane Proteine, Membrane Biology, Membrane Biochemistry

The objective of the Collaborative Research Center, CRC 807, is to elucidate the structure, function, and mechanism of membrane proteins involved in transfer of matter and information across cell membranes. Research interests range from small functional units to large, highly dynamic multi-subunit assemblies in subcellular compartments. Methods cover X-ray crystallography, cryo-electron microscopy, solid-state and solution NMR, pulsed EPR, time-resolved visible and infrared spectroscopy, single-molecule fluorescence techniques, super-resolution microscopy, native mass spectrometry, electrophysiology, and computational biophysics. Members of the CRC 807 (Sonderforschungsbereich SFB 807) collaborate on integrative biological questions, applying as well as developing advanced methodology. As many important questions cannot yet be answered by routine approaches, the development of methods constitutes an integral part of the CRC 807. Thus, the
CRC 807 rests on a well-balanced combination of enthralling topics, timely questions, and new approaches, probing the structure, function, and mechanism of membrane proteins.

The CRC 807 focuses on five subtopics: (i) secondary active transporters, (ii) ABC transporters, (iii) 7TM receptors and retinal proteins, (iv) rotary ATPases, and (v) membrane complexes. This outline implies a gradual increase in complexity. Hence, our CRC application spans the range from single transporter/receptor units to dynamic multi-component membrane assemblies, which will be a major challenge in life sciences.



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