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Kühlbrandt (P1) | Glaubitz (P6) | Prisner (P7) | Forrest (P8) | Abele (P9) | Tampé (P16)

P16 Tampélinie

Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins that hydrolyze ATP to drive solute transport. The ABC transporter superfamily forms the largest class of transporters in prokaryotes, and the second largest class in eukaryotes. They are involved in many cellular processes and transport a wide variety of substrates across membranes, ranging from ions, sugars and amino acids, antibiotics, drugs and lipids to large proteins of ~100 kDa. The (dys) function of several of these transporters is central to various human pathologies such as cystic fibrosis, adrenoleukodystrophy, retinal degeneration, hypercholesterolemia, tumor development and virus persistence. Moreover, ABC transporters play important roles in intracellular transport processes and organelle biogenesis, and in protecting organisms from xenobiotics. In this SFB, we will focus on multidrug efflux pumps, a new lysosomal ABC transport system, and the transporter associated with antigen processing.

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