Principal Investigators

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Bamberg, Ernst (P10)

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Max Planck Institute of
Biophysics, Frankfurt a.M.
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Bernhard, Frank (P2)

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Institute of Biophysical Chemistry
Goethe-University Frankfurt a.M.
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Dötsch, Volker (P2)

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Institute of Biophysical Chemistry
Goethe-University Frankfurt a.M.
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Fendler, Klaus (P10)

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Max Planck Institute of
Biophysics, Frankfurt a.M.
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Forrest, Lucy (P8)

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Computational Structural Biology
Max Planck Institute for
Biophysics, Frankfurt a.M.
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Glaubitz, Clemens (P6)

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Institute of Biophysical Chemistry &
Center for Biomolecular
Magnetic Resonance
Goethe-University Frankfurt a.M.
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Kühlbrandt, Werner (P1)

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Structural Biology
Max Planck Institute of
Biophysics, Frankfurt a.M.
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Mäntele, Werner (P5)

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Institute of Biophysics
Goethe-University Frankfurt a.M.
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Michel, Hartmut (P3)

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Moelcular Membrane Biology
Max Planck Institute of
Biophysics, Frankfurt a.M.
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Ziegler, Christine (P4)

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Dep. of Structural Biology
Max Planck Institute of
Biophysics, Frankfurt a.M.
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Secondary Active Transporters

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Secondary transporters convert the free energy stored in electrochemical gradients into a substrate concentration gradient. This process takes place using substrate/ion antiport or symport. Although close to ten X-ray structures, including contributions from Frankfurt, have been determined, a detailed understanding of a universal structure-function relationship has not been achieved so far. Therefore, a proteome-wide approach as well as in-depth molecular studies on selected proteins is proposed.

A proteome-wide analysis of transporters from E. coli and of selected transporter families from Aquifex aeolicus, Salmonella typhimurium, Pyrococcus furiosus and Homo sapiens will be carried out. A systematic screen of expression conditions using cell-free expression systems aims at finding suitable candidates for further structural and functional analyses. In a collaborative effort these proteins will be further characterized by electron paramagnetic resonance, FTIR spectroscopy, and electrophysiology.

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