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Projects

(Project-Number and Title / Research Area / Principal Investigator/s)

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P1  Structure and function of archaeal transporters

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Biophysics, electron microscopy, protein crystallography
Prof. Dr. Werner Kühlbrandt, Dep. of Structural Biology, Max-Planck-Institute of Biophysics, Frankfurt a.M.

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P2  Synergies of cell-free expression systems and NMR spectroscopy for the analysis of membrane proteins

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Liquid state NMR, biochemistry of membrane proteins
Prof. Dr. Volker Dötsch / Dr. Frank Bernhard, Institute of Biophysical
Chemistry, Goethe-University Frankfurt a.M.

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P3  Structural genomics on selected families of secondary active transporters

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Biochemistry, structural biology
Prof. Dr. Hartmut Michel, Molecular Membrane Biology, Max-Planck-Institute of Biophysics, Frankfurt a.M

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P4  Structure and function of the betaine transporter BetP from Corynebacterium glutamicum

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Biophysics, structural biology, protein crystallography
Dr. Christine Ziegler, Dep. of Structural Biology, Max-Planck-Institute of Biophysics, Frankfurt a.M.
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P5  Structural properties, activation mechanisms and transport processes in betaine transporter BetP and Na+/H+ antiporters NhaA/MjNhaP1 investigated by FT-IR and CD spectroscopy

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Biophysics, biophysical chemistry, molecular spectroscopy
Prof. Dr. Werner Mäntele, Institute of Biophysics, Goethe-University Frankfurt a.M.
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P6  Structure and function of bacterial multidrug efflux pumps

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Membrane biophysics, membrane biochemistry, soldi-state NMR, active transport, multidrug efflux
Prof. Dr. Clemens Glaubitz, Institute of Biophysical Chemistry, Goethe-University Frankfurt a.M.
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P7  Dipolar EPR spectroscopy on membrane embedded transport complexes

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Biophysics, EPR spectroscopy
Prof. Dr. Thomas Prisner, Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt a.M.
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P8  Computational studies of alternating access mechanisms in sodium-dependent secondary transporters

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   Molecular modeling, bioinformatics and simulation
   Dr. Lucy Forrest, Computational Structural Biology Group,  

   Max-Planck-Institute of Biophysics, Frankfurt a.M.
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P9  Function, mechanism and dynamics of the lysosomal transport complex ABCB9

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Membrane biochemistry, structural biology, cell biology

PD Dr. Rupert Abele, Institute of Biochemistry, Goethe-University Frankfurt a.M.

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P10  Light gated ion channels and secondary active transporters: mechanism and application

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Biophysics, transport mechanism, electrophysiology, spectroscopy
Prof. Dr. Klaus Fendler / Prof. Dr. Ernst Bamberg, Max-Planck-Institute of Biophysics, Frankfurt a.M.
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P11  Channelrhodopsin-2 and Halorhodopsin - optogentic tools for fast, non-invasive manipulation of neuronal circuits

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Photo-activated ion-channels & -pumps, membrane protein engineering, neurobiology, neurotransmission, cell biology

JunProf. Dr. Alexander Gottschalk, Institute of Biochemistry, Goethe-University Frankfurt a.M.

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P12  Photoinitiated functional dynamics of retinal proteins and multidrug transporters

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Biophysics, physical chemistry, molecular spectroscopy
Prof. Dr. Josef Wachtveitl, Institute of Physical and Theoretical Chemistry & Institute of Biophysics, Goethe-University Frankfurt a.M.

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P13  NMR investigations of mammalian rhodopsin

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      NMR-spectroscopy, structural biology, organic chemistry

      Prof. Dr. Harald Schwalbe, Institute of Organic Chemistry & 

      Chemical Biology, Goethe-University Frankfurt a.M.

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P14   ATP synthases: strucutre and function of unique enzymes from bacteria and archaea

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     Microbiology, biochemistry
     Prof. Dr. Volker Müller, Institute of Molecular Biosciences, 

     Goethe-University Frankfurt a.M.

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P15  Structure and function of bacterial F-ATP synthases

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Biochemistry, structural biology

Dr. Thomas Meier, Dep. of Structural Biology, Max-Planck-Institute of Biophysics, Frankfurt a.M.

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P16  Viral and intrinisic modulators of the macromolecular MHC I peptide-loading complex

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Membrane biochemistry and biophysics, ABC transporter

Prof. Dr. Robert Tampé, Institute of Biochemistry, Goethe-University Frankfurt a.M.

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P17  Dynamics, function and structural composition of the Toc-core complex

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Membrane biochemistry, plant physiology

Prof. Dr. Enrico Schleiff, Institute of Molecular Biosciences, Goethe-University Frankfurt a.M.

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P18  Structure and function of Resistance Nodulation and cell Division (RND) transporters and RND-type tripartite complexes

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Membrane biochemistry, structural biology, multidrug efflux

Prof. Dr. Klaas Martinus Pos, Institute of Biochemistry, Goethe-University Frankfurt a.M.

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