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April 22, 2015 - 17.00 h s.t., Seminar Room 0.15/N100
Structural basis of bacterial multi drug efflux transport
Prof. Dr. Akihito Yamaguchi, Osaka University / Japan

July 13-16, 2015 - Ellwangen Conference Center Schönenberg
SFB 807 Retreat 2015
Registration for SFB 807 members, co-workers & TRAM-students is open now!

April 29, 2015 - 17.00 h s.t. Seminar Room 0.15 / N100
Nucleotide-binding domain motions during gating in CFTR channels, the ABC proteins whose dysfunction causes cystic fibrosis
Prof. Dr. David Gadsby, The Rockefeller University, New York, USA

Integration of Biological Questions and Advanced Methodology

 

The consortium combines a large set of biochemical and biophysical methods to elucidate the molecular details of transport and signaling processes across membranes. This entails the determination of the chronological order of key events during a transfer cycle, their timescales and their structural basis. In particular, the presumed ability of transporters and receptors to adopt multiple conformations, which are required for completion of a full activity cycle, requires the identification of these essential conformational states and an understanding of how interchange between them occurs.

Our long-term goal is to determine whether generally valid principles, such as e.g. alternating access, holds true for all transporters or whether transport activity is based on evolutionarily diverse mechanisms. Another intriguing question is how the similar molecular architecture of 7 TM proteins is used for pumps, channels and receptors. A number of well-selected proteins and a large set of advanced methodologies to characterize the spatiotemporal arrangement of these systems are required.

 

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