October 14, 2015 - 17.00 h s.t. seminar room 0.15 / N100
SFB 807 - Workshop on
P11 Gottschalk & P14 Müller

October 28, 2015 - 17.00 h s.t. Seminar Room 0.15 / N100
New fluorescence based tools for the analysis of protein function and biomolecular interactions in cells and tissue
Prof. Dr. Ulrike Alexiev, FU Berlin

November 11, 2015 - 17.00 h s.t., Seminar Room 0.15/N100
Learning by building: what we learn on K+ channel function by engineering complex channels from simple units
Prof. Dr. Gerhard Thiel, TU Darmstadt

Integration of Biological Questions and Advanced Methodology


The consortium combines a large set of biochemical and biophysical methods to elucidate the molecular details of transport and signaling processes across membranes. This entails the determination of the chronological order of key events during a transfer cycle, their timescales and their structural basis. In particular, the presumed ability of transporters and receptors to adopt multiple conformations, which are required for completion of a full activity cycle, requires the identification of these essential conformational states and an understanding of how interchange between them occurs.

Our long-term goal is to determine whether generally valid principles, such as e.g. alternating access, holds true for all transporters or whether transport activity is based on evolutionarily diverse mechanisms. Another intriguing question is how the similar molecular architecture of 7 TM proteins is used for pumps, channels and receptors. A number of well-selected proteins and a large set of advanced methodologies to characterize the spatiotemporal arrangement of these systems are required.