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News


March 16-17, 2015 Kaiserslautern
2nd Network Meeting with IRTG 1830 & TRAM/SFB807
TU Kaiserlautern

15th April, 2015
Start of the next seminar and guest lecture series of the SFB 807 - Membrane Transport
Summer term 2015

July 13-16, 2015 - Ellwangen
SFB 807 Retreat 2015
Conference Center Schönenberg

Integration of Biological Questions and Advanced Methodology

 

The consortium combines a large set of biochemical and biophysical methods to elucidate the molecular details of transport and signaling processes across membranes. This entails the determination of the chronological order of key events during a transfer cycle, their timescales and their structural basis. In particular, the presumed ability of transporters and receptors to adopt multiple conformations, which are required for completion of a full activity cycle, requires the identification of these essential conformational states and an understanding of how interchange between them occurs.

Our long-term goal is to determine whether generally valid principles, such as e.g. alternating access, holds true for all transporters or whether transport activity is based on evolutionarily diverse mechanisms. Another intriguing question is how the similar molecular architecture of 7 TM proteins is used for pumps, channels and receptors. A number of well-selected proteins and a large set of advanced methodologies to characterize the spatiotemporal arrangement of these systems are required.

 

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